Hi there i was diagnosed in june 2018 and started imatinib. But it did not respond well and cml reached to blast phase. I started dasatinib along with chemo therapy and came back to chronic. My blast was 40% and now i have 1%. My latest bone marrow shows no atypical cell and no marrow fibrosis. My doc suggest me to have transplant. Is it good to have transplant? I have done my first bcr abl test since diagnosed and it shows 25%. Is it good or bad? Suggestion on this matter please.
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You were diagnosed in June 2018 and imatinib failed you. You started dasatinib and was successful in returning to chronic phase (blasts ~ 1%) which is good. Your latest bone marrow shows no sign of CML?, but your PCR shows 25%? That makes no sense. Was your bone marrow tested by FISH?
You may not need to change drugs and certainly not a transplant depending on what is data is actually correct. 1% blasts is in the normal range for patients and non-patients alike.
Hi scuba thanks for reply.
my doc said i m in remission. May be i am back to chronic phase. Bone marrow report says no marrow fibrosis no atypical cell.
It depends on how long you were taking Gleevec. If you only recently (3 months or less) started taking Dasatinib then 25% is probably not the worst result. However, If you have been taking it for a long time and are at PCR 25% then it is not an ideal result. It is good to have returned to Chronic Phase but I would get a lot more information from my doc than you currently have shared before deciding to go for a transplant. A second opinion is probably something I would do under any circumstance before going that route.
FYI I was at 23% after 3 months on Dasatinib. 1.8% after 6 months, and 0.111% at 16 months. So as you can see I missed the 3 month mark, hit the 6 month mark and am trending the right way to get under 0.1% by 18 months. Some people respond different/faster than others but the trend and rate of decline is something that you should probably look at in deciding what treatment option to go to next.
This site/forum has been a great resource for me and I thank God for all of the options available to me and for everybody that contributes here.