Glossary beginning with T

A glossary of terms.

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T

Tasigna: The commercial name for nilotinib.
Thrombocytopenia: The condition of having abnormally low numbers of platelets.
Thrombocytosis: The condition of having abnormally high numbers of platelets.
TKI: Tyrosine Kinase Inhibitor (TKI), a molecular targeted therapy designed to block specific proteins that cause leukaemic cells to divide. Imatinib was the first generation in this class of oral therapy; dasatinib, nilotinib, bosutinib and ponatinib are second generation TKIs now used as 1st, 2nd, 3rd and 4th line therapy.
Translocation: An event that occurs when part of one chromosome breaks off and attaches to a different chromosome. In 1973, Janet D. Rowley at the University of Chicago described the mechanism by which the Philadelphia chromosome arises as a reciprocal translocation between chromosomes 9 and 22.
Tyrosine kinases: proteins that play a key role in cell signalling processes.