Hello all! I had a dr visit today and I'm very excited to say that my wbc is 4.4 ( down from 59.5), my platelets are 187. I'm very thankful for these TKIs! Having said that I just completed week 4 of sprycel 100 mg on e daily. I am in excruciating pain- forearms, wrists, thighs, knees, feel basically like I have the flu magnified by 10! I have Vicodin from my primary that I was given at the onset of my dx due to severe back pain. I told my oncologist today that I'm taking 2- 5mg every 4-6 hrs. It helps for about 1 1/2 hrs then I have to wait 4 hrs to take more. He said I should only go tgru him for meds, lowered my sprycel to 70 my and told me to take Tylenol. I like my dr. I'm in USA. Just wanted some feedback about how others handle pain while taking TKIs. Many thanks!! Blessings peeps.