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OK! Just took my first 100MG Sprycel Pill today

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Ready for the roller-coaster ride for side effects !

Just finished 2-  500.ML bottles of spring water and will drink another 2 during the course of the day.

2 LR about right?

 

 

 

If your white blood count was high at your diagnosis like say over 100k.
the first month or so you will have a harder time then if your WBC was low.
The first thing that will happen is the lukemic white blood cells will start to die off
in mass and your body will need to get rid of these dead cells.
After your WBC are more normal then the long term side effects will set in.
Don’t assume that how you feel at first treatment will be the norm.
If your WBC were low like say 30K or so, it won’t be too bad.
Mine was 170k. The first two months were difficult for me.
It’s does get better.

Good luck

Romo

Best of luck Chuckster. Hope the Sprycel zaps your CML fast and hard.

My husband probably drinks closer to 4 litres daily ( I know , lots of loo stops) . He drinks it at room temperature otherwise he ends up freezing. He does generally feel much colder as well so be prepared to pile on the layers. 

Louise 

Hi Romo!

Thanks for the info

 

My latest WBC the end of Feb was at 19K.

Which was up from 14.9k in Jan.

 

 

 

 

 

Thanks!

Chuckster:

I don't think that you need to drink that much water.  However, I was told that Omeprazole for indigestion can affect the potency.  I take the Omeprazole in the AM with most of my meds and I take my Sprycel at night with just a sip of water.  My PCR went from 77 in January 2017 to .015 IS three months ago.  I was tested again this morning and will receive the results on Friday.  I started at 100 mg but I am now at 20 mg.  Good luck but stay relaxed - it is a miracle drug!

Omeprazole with dasatinib is not a good idea, even when taken far apart in the day. Dasatinib needs the acid in your stomach to break it down properly, the very thing which omeprazole neutralises over the whole day.

If possible, manage reflux with gaviscon / gastrocote or similar but don't taken them within 2 hours of each other. 

I used to have terrible reflux, and here's my PCR results before and after getting rid of omeprazole. 

  • Aug  13: 0.489%
  • Sept 13: 1.04%
  • Nov 13: 0.131%
  • Nov 13: 0.284%
  • Jan 14: 0.369%
  • At this point (March 14), omeprazole was withdrawn
  • Apr 14: 0.131%
  • Aug 14: 0.06%
  • And then continually and steadily down to MR 4.5.

David.